Quinolines and derivatives
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Filtered Search Results
MEDCHEMEXPRESS LLC Foliglurax monohydrochloride | 2133294-96-7 | 98.57% | 457.97 | 10 MG
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Foliglurax monohydrochloride is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM), with an EC50 of 79 nM. It exhibits an antiparkinsonian effect.
- Highly selective and potent.
- Brain-penetrant mGluR4 PAM.
- EC50 of 79 nM for mGlu4.
- Exhibits antiparkinsonian effect.
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MEDCHEMEXPRESS LLC CX516 | 154235-83-3 | 99.94% | 241.29 | 100 MG
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CX516 (BDP 12) is an ampakine that functions as an AMPA receptor positive allosteric modulator. It is used in the research of Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI).
- Acts as an AMPA receptor positive allosteric modulator.
- Used in research for Alzheimer's disease, schizophrenia, and mild cognitive impairment (MCI).
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MEDCHEMEXPRESS LLC Tivozanib | 475108-18-0 | 99.8% | 454.86 | 100 MG
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Tivozanib is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR)-1, 2, and 3. It demonstrates antitumor efficacy and is suitable for research use.
- Selectively inhibits VEGFR-1, 2, and 3 with low nanomolar IC50 values
- Inhibits VEGF-induced proliferation and migration of HUVECs
- Exhibits antitumor efficacy across various cancer models in athymic mice
- Reversibly suppresses vascular permeability and angiogenesis
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MEDCHEMEXPRESS LLC Tavaborole | 174671-46-6 | 99.7% | 151.93 | 1 ML
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Tavaborole is an antifungal agent primarily active against Trichophyton species, developed as a topical solution for the treatment of onychomycosis. It is intended strictly for research purposes and not sold to patients.
- Antifungal agent with activity against Trichophyton species.
- Used in a topical solution formulation for the potential treatment of onychomycosis.
- Demonstrates an 8-fold increase in activity against C. neoformans and A. fumigatus in vitro.
- Inhibits cells expressing GlLeuRS-D444A.
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MEDCHEMEXPRESS LLC LM11A-31 (dihydrochloride) | 1243259-19-9 | 99.9% | 316.27 | 25 MG
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LM11A-31 dihydrochloride is a non-peptide p75NTR (neurotrophin receptor p75) modulator and an orally active, potent proNGF (nerve growth factor) antagonist. It is an amino acid derivative that readily crosses the blood-brain barrier and inhibits p75-mediated cell death. This compound has been shown to reverse cholinergic neurite dystrophy in mouse models of Alzheimer's disease during mid- to late-stage disease progression. It is intended for research use only and is not sold to patients.
- Non-peptide p75NTR modulator
- Orally active and potent proNGF antagonist
- Amino acid derivative with high blood-brain barrier permeability
- Blocks p75-mediated cell death
- Reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models
- Mitigates proNGF accumulation and preserves BRB integrity in animal models
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AMBEED
NC3997553 DEVIMISTA CAS 95809-78-2 200MG
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MEDCHEMEXPRESS LLC Sulfo-Cy3 amine | 2183440-43-7 | 99.7% | 714.93 g/mol | C36H50N4O7S2 | 10 MG
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Sulfo-Cy3 amine is a water-soluble Cyanine3 derivative containing a primary amine for covalent conjugation to biomolecules. The sulfonate groups increase aqueous solubility and the dye provides bright, photostable fluorescence for imaging and detection applications. Soluble in DMSO; may require ultrasonication and dry DMSO for best results.
- Water-soluble sulfonated Cy3 derivative suitable for aqueous labeling.
- Primary amine functional group for conjugation to electrophiles and carboxyl groups.
- High purity for consistent labeling performance.
- Soluble in DMSO (125 mg/mL); may require ultrasonication and newly opened DMSO.
- Bright, photostable fluorescence for imaging and detection applications.
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MEDCHEMEXPRESS LLC Cyanine5.5 amine | 2097714-45-7 | 753.88 | C46H58Cl2N4O | 10 MG
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Cyanine5.5 amine is a near-infrared fluorescent dye bearing a reactive amine group for conjugation to biomolecules, nanoparticles, and polymers. It exhibits excitation at 680 nm and emission at 710 nm, making it suitable for low-background imaging in confocal and fluorescence microscopy applications.
- Near-infrared excitation and emission (680 nm/710 nm) for reduced autofluorescence.
- Amine functional group enables straightforward conjugation to proteins and nanoparticles.
- Appropriate for confocal and fluorescence microscopy and fluorescence-based tracking.
- Available in small and bulk pack sizes to support scouting experiments and scale-up.
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MEDCHEMEXPRESS LLC Mefloquine | 53230-10-7 | 100.0% | 378.31 g·mol-1 | C17H16F6N2O | 10 MG
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Mefloquine is an orally active quinoline antimalarial agent used in biomedical research. It has reported activity as an inhibitor of SARS-CoV-2 entry and as a K+ channel antagonist (IC50 ≈1 μM). Supplied as a solid for research use only; not intended for clinical or human therapeutic use.
- High purity (HPLC 99.96%).
- Chemical formula C17H16F6N2O; molecular weight 378.31 g·mol-1.
- CAS number 53230-10-7.
- Common uses: malaria, autoimmune disease, and oncology research.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
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NEW AGE INDUSTRIES INC
NC4014212 3/8 X 1/2 ZELITE
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MEDCHEMEXPRESS LLC L-Cystathionine dihydrochloride | 61125-50-6 | MFCD00136759 | 99.8% | 295.18 | 100 MG
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L-Cystathionine dihydrochloride is a nonprotein thioether and a key amino acid associated with the metabolic state of sulfur-containing amino acids. It protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs) and plays an important role in cardiovascular protection.
- Nonprotein thioether
- Key amino acid associated with the metabolic state of sulfur-containing amino acids
- Protects against homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs)
- Plays an important role in cardiovascular protection
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MEDCHEMEXPRESS LLC L-Cystathionine dihydrochloride | 61125-50-6 | 99.87% | 295.18 | 50 MG
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L-Cystathionine dihydrochloride | 61125-50-6 | 99.87% | 295.18 | 50 MG
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MEDCHEMEXPRESS LLC BREXPIPRAZOLE 200 mg
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BREXPIPRAZOLE 200MG
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MEDCHEMEXPRESS LLC HJC0350 200 mg
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HJC0350 200MG
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MEDCHEMEXPRESS LLC PRMT5-IN-31 5 mg
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PRMT5-IN-31 5MG
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